The system performs well in reducing the level of noise in the final HR image, due to the denoising step and the mean fusion process.
An L 2-norm minimization approach, which is essentially taking the pixel-wise mean of the aligned images, is performed to produce the final HR image.
After estimating the low-frequency part Y h of the final HR image X h, we just need to restore the high-frequency part and then add it to Y h.
We give examples (ACT I and UKHAN_2) where interim HRs are close to or exceed 1.0, with low CP, but the final HR indicated a clinically important effect.
The final HR was adjusted for sex, education (primary or less, more than primary but less than college or university, or college or university), alcohol consumption [low (0 g/d), medium (men >0 40 g/d and women >0 20 g/d), and high (men >40 g/d and women >20 g/d)], smoking status (never, former, or current), energy intake (kcal/d), and vigorous physical activity (yes or no).
During each exposure session, subjects completed ratings and tests before H2S exposure (baseline) and during the final hour of the 2-hr exposure period.
H719 and A549 cells were treated with [3H]-5-aza-CdR at 1 µM for 48 hrs with or without depsipeptide at 0.1 µM for the final 6 hrs (from 42 to 48 hrs) and the cells were then washed with cold PBS.
In the study shown, tissue was cultured +/−RH5992 (5 ug/ml) for 24 hrs, and either received BrdU for the entire 24 hr period ( Fig. 9E ), or for only the final 6 hrs of culture ( Fig. 9F ).
To control for the possibility that mechanical stimulation/fatigue and not sleep loss per se is responsible for reduced aggression, we mechanically stimulated flies for a 6 hr period spanning the final 3 hr of night and first 3 hr of day.
Cells were treated with [3H]-5-aza-CdR at 1 µM for 48 hrs, with and without depsipeptide at 0.1 µM for the final 6 hrs of treatment, and the cells were then washed and replaced in fresh medium (without experimental reagents) for 6, 12 and 24 hrs. Figure 6A shows that incorporated [3H]-5-aza-CdR gradually decreased during incubation in [3H]-5-aza-CdR free medium.
