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Screen sizing influenced nucleation and produced significant differences in the final granule size distribution.
The final granule size distribution was also observed to become narrower with increased bed temperature and fluidising air velocity.
A seasonality effect could be put into evidence that impacted further processing through its influence on the final granule size.
The wet granule breakage process in a high shear mixer will influence and may control the final granule size distribution.
This signal can be used for a tight control of the granulation process and leads to a low batch to batch variability in the final granule size distribution.
Moreover, it was demonstrated by means of a PLS that a relation between the particle size and the MRT measurements can be quantitatively defined, highlighting a potential ability of the MRT sensor to predict information about the final granule size.
Similar(53)
Control of nucleation in wet granulation often determines the size and structure of the final granules.
The purpose of this study was to determine the influence of inlet air humidity changes on temperature in different parts of a granulator system, on fluidisation behaviour and on the particle size of the final granules.
For the first time, the distribution of primary particles among different size fractions of the final granules was investigated computationally, together with experimental validation.
Scanning Electron Microscopy (SEM) was used as a complementary tool with particle size analysis to evaluate the effect of the material properties on the quality attributes of the final granules and provide further insight into the growth mechanisms.
A multilayer perceptron neural network was developed using MATLAB neural network toolbox and the evaluated quality attributes of the final granules were used as a database for the development and selection of the optimal architecture of the ANN model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com