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The facilitating function of the B chain was equally effective whether or not its lectin site was active.
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We surmise that the facilitating function of TSPY in the cell cycle was less obvious because the synchronization was at metaphase, immediate beyond the G2 stage in which TSPY is postulated to be effective in expediting cell cycle progression.
The motility facilitating function of gelsolin has been widely observed in animal models [ 26- 29].
The importance of a surface-exposed strong positive electrostatic groove for rugose biofilm formation was identified, and it was postulated that this region was required for interactions with other matrix components, such as the VPS, to facilitate the function of RbmA as a scaffold in the biofilm matrix (Giglio et al. 2013).
Alternatively, the polymorphisms could be within the organellar genes that are required to facilitate the function of the several thousand nuclear genes whose protein products are transported into the organelles and function there (Ajjawi et al., 2010).
In some assays, the requirement for the 18 aa motif in EFA-6 function was not all-or-none, suggesting it may facilitate the function of the surrounding interacting domain.
It is believed that cohesin, in yet to be uncovered fashion, facilitates the function of the multipurpose transcriptional regulator CTCF [ 19], at a subset of thousands of CTCF sites in the genomes of Metazoa where cohesin and CTCF colocalize [ 20, 21].
Such contacts may in turn facilitate the function of adhesive signaling molecules, such as the ephrin-A5 and EphA5 receptors, both of which are predominantly expressed at the neonatal period (Figure 1C).
The complex has a major role in the repair of DNA lesions directly by facilitating DNA accessibility on the chromatin or indirectly by facilitating the functions of DNA repair proteins, such as p53, BRCA1, GADD45 and Fanconi Anemia proteins (Reisman et al, 2009).
Moreover, we show that the increased expression of Ago2 will facilitate the function of miR-375 in suppressing genes, including Cadm1 in vivo.
An epistatic analysis of the relationship between chiron, a GSK3 inhibitor, and Tcf3 has led to the suggestion that the main role of β-catenin in self-renewal is to compete the activity of Tcf3 and thus facilitate the function of Nanog, Oct4 and Sox2 (Wray et al., 2011).
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