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Beyond leading the specification of the requirements of clinical information systems supportive of personalized medicine, the Collaboratory could internally develop and/or fund the external development of HITSP-compliant approaches to fulfilling the CCHIT certification criteria in relation to personalized medicine.
Open business models therefore work best if a firm leverages the external development.
The external development model allowed Wideload to focus on the creative aspect of a project and added flexibility in what types of projects the team could take on.
Taking advantages of the external development and optical clarity of zebrafish embryos, we showed that the histone modification can be easily detected by fluorescent staining (Figure S1).
Considerable advantages are the external development of embryos and optical clarity during embryogenesis which facilitate the analysis of early developmental processes as well as disease progression.
As a case study I compared the external development of 23 land vertebrate species with a focus on turtles, mainly based on reference staging tables.
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Furthermore, this external development allows for the precise timing and dosage of ethanol exposure.
The rapid external development of easily manipulatable translucent embryos together with the efficient husbandry has sparked the establishment of many models of human diseases in zebrafish, and these models often closely resemble the human condition (Lieschke and Currie, 2007).
The particular advantages of zebrafish, such as the high fecundity, rapid external development and the extraordinary optical clarity of the embryos, allow easy analysis of histone modifications and gene expressions by means of immunostaining and whole-mount in situ hybridization (WISH) strategies.
The interview developed were an open-ended, discovery-oriented, and semi-structured questionnaire, which was conducted to understand pastoralists' insight, feeling, thought, and opinion about the impact of external development interventions and their perception towards climate change settings and the emerging mitigation and adaptation strategies among members of the community.
The main role of the GAR consultants was to oversee the methodological processes in external development of guidelines, particularly reviewing and classifying the quality of the evidence, and how these classifications correlated to the resultant recommendations.
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