Sentence examples for the extent of potency from inspiring English sources

Thus, even if favorable geometries might be achieved by truncated taxanes, a combination of fewer ligand protein contacts, alternative binding poses, and an entropy disadvantage for reduced scaffolds may well limit the extent of potency equivalency relative to the taxanes, epothilones, and other agents known to bind the taxane site.

The extent of the neutralizing potency of different scFvs was in agreement with that of their parental full-length MAbs (Table 2).

This DOM-KETO coadministration study provided the opportunity to establish the usefulness, as well as limitations, of in vitro in vivo extrapolation modeling and simulation in predicting the extent of the proarrhythmic potency of CYP (cytochrome P450) enzyme substrates in the presence of inhibitors.

Indomethacin-coumarinylamide (5) was a highly potent and selective COX-2 inhibitor, and as the coumarin fluorophore was replaced by an uncharged dansyl fluorophore, the extent of COX-2 selectivity and potency of the conjugate (15) remained unchanged.

Synthetic estrogens are also of great interest due to their high estrogenic potency and the extent of their use.

These results demonstrate that cell death initiation upon CII inhibition depends on ROS and that the extent of cell death correlates with the potency of inhibition at the Qp site unless intracellular succinate is high.

In particular, we focus on endocrine-active steroid hormones because of their widespread use as pharmaceuticals, the extent of available pharmacology knowledge, their demonstrated potency, and their link to sublethal effects in aquatic organisms.

Using the measured airborne concentrations or emission rates of these compounds as an indication of the extent of their use, together with their predicted potencies, provides an efficient method to prioritize the experimental assessment of contact sensitization of untested organic compounds that can be detected as air pollutants.

This category includes the range of scenarios about the potency of hazards and the extent of risks.

The decrease in potency was dependent on the extent of removal of the coplanar and mono- ortho-substituted PCBs, consistent with the known mechanism of this effect.

Our data not only confirmed that p-STAT3 is a target of sorafenib, but also suggested that the extent of p-STAT3 inhibition may be correlated with drug potency in these p-STAT3 inhibitors.