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In fact, the identified MRs by VIPER are scored based on their exerted effects on their downstream targets in that the more distinction observed in the expression degrees of the MR targets between cases and controls leads to a higher enrichment score demonstrating the higher activity of that MR. Our findings in this study are in line the findings from co-expression network analysis in1.
The expression degrees of COL2A1, COL1A2, and COL10A1 genes in the regenerated tissues were twice or more as large as those in the normal cartilage.
The expression degrees of SPARC, FLOD2, CHAD, CTGF, and COMPs genes in the regenerated tissues were twice or more as large as those in the normal cartilage.
Behavioral changes in the mdr 1a/1b knockout mice in comparison to the wild-type mice allow for the investigation of P-gp-dependent variations in the expression degrees of the CNS which leads to functional dispositions.
This result indicates that the expression degrees of present probe sets located in the mix-, S- and sat-ranges of the original hooks remain, on the average, essentially unchanged after updating the probe sets.
The expression degrees of DCN and FMOD genes in the regenerated tissues were twice or more as large as those in the normal cartilage, and the expression degree of GPC6 gene in the regenerated tissues was quarter as little as those in the normal cartilage.
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The expression degree of dkr in Erwinia strains was evaluated through the production titer of 2-KLG, and the highest productivity rate of 6.6 g L-1 d-1 was achieved with Erwinia citreus, mutant strain ER1026 (Grindley et al. 1988 ).
Interestingly, as the focus score (grade) increased, the expression degree of TLR2, TLR4, and TLR6 increased.
The expression degree of COL2A1, COL1A2, COL10A1, DCN, FMOD, SPARC, FLOD2, CHAD, CTGF, and COMP genes was greater in the regenerated tissue than in the normal cartilage.
In the extraction of TFs and their regulated genes, the TF was also cited from the TRANSFAC database [ 19], but the expression degree of the TF was not considered, due to the small expression changes even under different conditions.
The so-called degradation hook-plot, shown in Figure 1a and b, displays this 3′/5′ intensity difference in dependence on the mean logged probe intensity approximating the expression degree of the respective gene.
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