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(Given the explanation of the Methods, it is impossible to tell).
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The explanation of the method and the demonstration of its applications should help researchers incorporate the beta-binomial method as they aggregate probabilities of events from heterogeneous studies.
A similar comment pertains to the flow chart in Figure 2. Therefore, I would suggest the authors take some pains to improve the clarity of the explanation of the method.
Also, the explanations of the method that are couched in first order logic-like notation are difficult to follow, because it is not stated whether the variant C can precede the start of the read (in which case C-S would be negative).
The reader is referred to the explanation of the S3D method in (Koch and Kuvshinov 2013) for further details.
The explanation of the computation method is detailed in supplementary figure S1 (Supplementary Material online).
In the revision, we expanded the explanation of the procedure under Methods (section on Analysis of Selection Pressures, 2 nd paragraph).
We have expanded the explanation of this method and its advantages in the corresponding part of the Materials and methods section, multi-model selection and inference: "Multi-model inference is increasingly recognised as an alternative approach the interest is in finding strong and consistent predictors of a particular outcome".
Second, make the explanation of the new iterative method for root.
Verbal agreements from participants were obtained following the explanation of the purpose and method of the study and the general content of interview.
The explanation of the study design & methods is clear.
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