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This disease reaction pattern agreed with the expected disease reaction attributed to the xa5 gene (Nino-Liu et al. 2006).
If susceptible individuals are replenished, either through loss of immunity of recovered individuals or through immigration of new individuals, then an endemic equilibrium may be reached in which the expected disease prevalence is constant.
Many of the best topics are much more consistent with the expected disease terms.
Comparing to results in table 2, the best topics are much more consistent with the expected disease terms.
Disease stage costs per patient were collected; the expected disease progression in the absence of treatment and sustained virological response (SVR) success rate for SOF-based regimens were calculated based on the literature and expert opinion.
This is highlighted by studies showing that the exclusive expression of a mutant protein in specific neuronal cell types affected in disease does not always lead to the expected disease phenotypes (Clement et al., 2003; Gu et al., 2005; Gu et al., 2007; Yamanaka et al., 2008a).
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This is likely to be explained by the small sample number and relative subtlety of the expected disease-related changes.
Alternatively, one can study a large cohort of unrelated individuals who share classic clinical features of recessive disease and observe that a subset of them manifest only one or no disease-causing variants in the coding sequences of the expected disease-causing gene.
This was not explained by the higher than expected disease severity and thus the large number of late stage patients in the overall population.
Recent literature has suggested the need for model-based approaches for surveillance in order to include other variables into the specification of expected disease incidence [ 14].
All PBS-dosed mice displayed expected disease with the peak average clinical score of 4 (Figure 1C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com