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The secondary aim of the discovery driven approach was to identify differentially abundant proteins detectable with the existing sample size.
Simulations showed sufficient power with the existing sample size.
Statistical power (1-β) for outcome differences in both GHb and systolic BP was > 99% considering the existing sample size.
However, the existing sample size did not allow a more in-depth examination of the effect of race and p53 mutation status on survival in the context of increased COX-2.
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Results Only 11/62 trials described existing sample size calculations fully and consistently in both the protocol and the publication.
Some insights are also provided on existing sample size formulae using our results.
The inconsistent predictive performance of several classifiers on both the original training data and later-generated validation data could be attributed in part to the data complexity of their respective chemical tissue conditions unresolved by computational modeling at their existing sample size.
The nature and size of the existing sample place it particularly well for the undertaking of mendelian randomisation experiments.
Here, the grid size for spatial prediction needs to be reasonably adjusted to the existing sampling scheme.
This procedure is effective as new active points take existing samples and their step sizes as the seed, and the step sizes of existing samples are appropriate for the newly-generated sample.
The existing literature on sample size formulae for CRCTs focuses largely on the case where there is no limit on the number of available clusters [ 3- 5, 11, 12].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com