Despite the established role of the TCA cycle in tumorigenesis, its involvement in cancer metabolism remains incompletely understood.
Earlier stage PFTC disease could also have better survival rates, given the possibility of presenting earlier and the established role of lymphadenectomy in its management.
Despite the established role of prolonged EEG/video in diagnosing PS, identification of suggestive features is still important for further diagnostic monitoring.
The established role of CGRP as a key mediator in migraine is underlined by a recent report on elevated CGRP plasma levels during the interictal phases in chronic migraine [59].
The authors acknowledge that the established role of silicon will mean that graphene, which is not a semi-conductor, might not play a part in processors till after 2021.
This is particular intriguing in light of the established role of NMD in setting up autoregulatory loops through AS-NMD.
In contrast, DZNep-induced EZH2 degradation was affected by Lactacystin (Figure S6C), which is in line with the established role of DZNep in inducing proteasome degradation [14].
This finding is exciting due to the established role of PDCD4 as a tumor suppressor and as a substrate of Akt [23], [25].
Provided that neovascularization is a valid marker for tumor angiogenesis, these results are in agreement with the established role of TSP-1 in tumor inhibition [30].
Due to the established role of RAF kinases in cancer, the search for inhibitors of RAF-MEK-ERK signaling has been intense [16].
However, in contrast to the established role of p53 in cancer prevention, a similar role of p73 in oncogenesis remains to be explored.
