Sentence examples for the essential target of from inspiring English sources

We have shown that Ypk1, a member of the AGC class of protein kinases conserved from yeast to humans, is the essential target of and activated via phosphorylation by the plasma membrane-associated TORC2 complex.

The essential targets of miR-200 include Zeb1 and Zeb2, two key transcription factors promoting the EMT process (Burk et al., 2008; Gregory et al., 2008; Korpal et al., 2008; Park et al., 2008).

Experiments in mice revealed that T cells but not macrophages are the essential targets of GC therapy [19].

Luciferase activity assays indicated that mutation of the essential target site abolished the effect of miR-328, while mutation of the non-essential site produced little effect of miR-328's repression activity (Fig 4D).

Regardless, the regulation of splicing might be an essential target of nuclear-enriched, stable lncRNAs that appeared recently in the history of the evolution.

The p16 tumor suppressor specifically blocks cyclin dependent kinase 4 (Cdk4) activity and blocked tumorigenesis by erbB2, demonstrating that deregulation of the cyclin dependent kinase partner of cyclin D1 is an essential target of erbB2.

In isolated mitochondria and in cells, Bcl-2 becomes an essential target of mutSOD1 and undergoes a conformational modification, exposing the toxic BH3 domain.

In conclusion, we define here the downregulation of anti-apoptotic protein Mcl-1 as a common hallmark and essential target of CGs.

T. brucei is the parasite which causes African sleeping sickness, a neglected tropical disease that affects thousands each year, and TbrPDEB1 has been shown to be an essential target of therapeutic relevance.

A recent study identified VCP as an essential target of oncogenic Akt signaling and was necessary for cell growth and survival [40].

83 It has been proposed that insulin-like growth factor (IGF -I acts as an essentIGF -Irget of GLP-2.