Sentence examples for the essential alterations from inspiring English sources

Many of the essential alterations occurring in cell physiology during carcinogenesis are mediated via extracellular cell signalling pathways that interact with intracellular circuits.

In general, the contributions of MAPK, CREB, and PTEN to the cell circuitry involved in carcinogenesis are also comprehensively summarized by Hanahan and Weinberg (2000) in their review on the essential alterations in cell physiology that establish malignant growth.

Calcium ion has been implicated either directly or indirectly in many of the essential alterations key for malignant growth (Hanahan and Weinberg, 2000), having been shown to be involved in proliferation (Becchetti, 2011), cell motility, (Huang et al, 2004), angiogenesis (Patton et al, 2003), resistance to apoptosis (Rizzuto et al, 2003) and transcriptional regulation (Rizzuto and Pozzan, 2006).

Is the essential alteration in them, in the environment or in both?

In that universe, the time coordinate of one coordinate system depends on both the time and space coordinates of another relatively moving system, forming the essential alteration required for Einstein's special theory of relativity.

As even minor temperature shifts strongly influence the growth and development in salmonids and cause essential alterations in life history patterns, any long-term non-adaptive variation in response to thermal conditions is likely to have important consequence on individual physiology and fitness [49].

The pathway of tumor formation is a multistep journey including at least six essential alterations in cell physiology that collectively dictate malignant growth and the spread of transformed cell clones [ 79].

These essential alterations in cell physiology are, amongst others, achieved by the constitutive activation of oncogenes and the loss of tumor suppressor gene (TSG) function.

They are six essential alterations of cell physiology that generally occur in cancer cells independently of the originating tissue type.

Neoplastic overgrowth involves essential alterations in cell physiology, loss of cell proliferation control and resistance to cell death.

Tumors are characterized by six essential alterations in cell physiology: self-sufficiency in growth signals, insensitivity to growth-inhibition signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis [ 2, 3].