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Starting with Nutlins as an initial lead, we designed and generated bicyclic scaffolds aiming to place cis-bischlorophenyl moiety at the equivalent location where the hydrophobic interaction with MDM2 could be expected.
Here's Street View at that first (more westerly) overpass, and here's the equivalent location: the site of the gray circle in the center of the map.
Interestingly, HCN channels also have an Arg residue (R484) on the extracellular side of the selectivity filter near the one found in Kir2.1 channels, however, have a Ser (S475) at the equivalent location for the negative counter ion (E138 of Kir2.1 channels) required to form a salt bridge.
An equally sized VOI was placed in the contralateral leg on the equivalent location, to serve as an internal control.
The position of the intron within the homeobox is at the equivalent location to that in UXA, DUXB, Duxbl and DUXC.
The cue appeared at one-quarter the distance between RF centre and fixation point, or at the equivalent location in the opposite visual hemifield on 'attend away' trials.
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The location the animal had to attend to was either at the centre of the RF or at an equivalent location in the opposite visual hemifield (on attend away trials).
An equal-sized VOI was placed in the contralateral leg at an equivalent location to where the implant was placed in the experimental leg.
These were calculated in 10 kb non-overlapping windows, which provide a good balance between test power and genomic resolution, across the whole 300 kb region centered on the selected SNP (or equivalent location in neutral simulations) in each individual set.
If the Germans had an equivalent location in America's capital, as symbolic as central, it would be next to the Washington Monument.
The affected skin of SSc patients and skin from an equivalent location in the controls was sampled.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com