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Lehman's demise marked the onset of the worst financial crisis and global recession since the 1930s.To be sure, the seeds of trouble had been sown years earlier, with the relaxation of lending standards in mortgages, corporate buy-outs and much more, and with the enthusiasm for using borrowed money to enhance returns.
8 The enthusiasm for using carcinogenic HPV testing in primary screening, however, has been tempered by its lower predictive value or absolute risk for cervical intraepithelial neoplasia grade II+ or III+ after a positive result compared with abnormal cytology.
However, despite its greater sensitivity and overall accuracy, the enthusiasm for using HPV testing in primary screening has been tempered by its somewhat poorer positive predictive value in comparison with cytologic analysis (e.g., 7.0percentt for HPV testing vs. 8.7percentt for Pap smears, using a threshold of atypical squamous cells of undetermined significance or worse (3)).
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Much of the enthusiasm for use of BBDR modeling in estimating low-dose risks may result from a general aversion to the default methods contained in U.S. EPA guidelines (e.g., U.S. EPA 2005).
However, the initial enthusiasm for using PI3K, Akt, or mTOR inhibitors as antineoplastic agents has been tempered by observations that such inhibition typically promotes growth arrest rather than cell death in solid tumors [ 19].
Several recent studies have somewhat dampened the initial enthusiasm for using PET for this purpose: for example, studies by Fehr and colleagues [ 59] and Barranger and colleagues [ 60] conducted in clinically node-negative patients both found a sensitivity of only 20% for F-FDG-PET compared with sentinel-node biopsy.
However, the cost of having to pay the Inland Revenue to send out notices of the change may, he thinks, curb the parliament's enthusiasm for using this facility.
Continuing refinements in radiotherapy treatment planning techniques as well as technical advances in ultrasound have further generated the resurgence of enthusiasm for using prostate brachytherapy to treat clinically localised prostate cancer.
And the government's apparent enthusiasm for using Canada's cuts strategy of the 1990s is unlikely to calm these fears.
Since the Kosovo war, American enthusiasm for using NATO as an "out-of-area" policeman has waned, in part because of the sheer incompetence demonstrated by European forces during the fighting.
But the people who run Russian finance have shown little enthusiasm for using the powers they already have.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com