Exact(3)
In an ideal world, we would have a randomized trial with the enormous sample necessary to answer this question as well as decades of follow-up.
Disentangling the relative contributions of genetic and environmental factors to the mechanism of a complex human disease such as MetS is daunting because of the expense of procuring the enormous sample sizes necessary to make statistically valid conclusions, particularly in the face of tremendous genetic and lifestyle variation.
On the other hand, the enormous sample size of pooled studies may amplify even the small individual effects, for example, due to platform effects, population strata, or genotyping batch effects, resulting in false positive findings, as heterogeneity between studies is amplified by imputation.
Similar(56)
(equation 4) This is plotted in the Figure, indicating that enormous sample sizes are required to ensure that the quarantine failure rate is <1%.
Mining the resulting terabyte or so of data will allow astronomers to investigate the evolution of galaxies, for example, since the SDSS will provide an enormous sample of them.And even the SDSS will represent only a single snapshot of the sky.
The P-criterion implies that an enormous sample size is required to identify a pathogenic variant of the average mutation rate.
This enormous sample size outweighs the disadvantage of plot-level increases in uncertainty when it comes to estimating uncertainty in the mean.
The CPS and ACS feature in-person interviews, enormous sample sizes and very high response rates, making them some of the most reliable surveys available.
For example, although over 60 SNPs have now been associated with BMD, for which the heritability is very high, the effect sizes of all are very small, and enormous sample sizes were required to identify these.
Although the possibility of the NGM cannot be entirely denied, the proof of the NGM may be extremely difficult because it requires such an enormous sample size.
Today, as on previous general election days, a consortium of pollsters spoke to over 20,000 voters outside polling stations around the country and asked them how they had voted an enormous sample based, unlike pre-election polls, on reported behaviour, not voters' intentions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com