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The enhanced longevity and pathogen-resistance of daf-2 or germline-deficient mutants require DAF-16 [9], [10] [11], [12], [14], [16], [16].
The incidence of the cardiorenal syndrome has increased due to the enhanced longevity of the population.
Thus, we hypothesize that the enhanced longevity of DAGL/ inaE EP1101 resulted from reduced TOR signaling, since DAGL/ inaE overexpression shunts more DAG into 2-AG and it should also lower PA levels (Fig. S2, Supporting information).
In both cases, the enhanced longevity was observed in two different fly strains, the outbred Wdah and the inbred w (Fig. 7A), indicating that it is robust to genetic background.
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Despite the male-specific enhanced longevity and oxidative stress resistance in dTSPO-depleted flies, the depletion of dTSPO on Aβ42-expressing flies was comparably protective for both male and female flies.
Further studies of these transcription factors under the sch9Δ, ras2Δ, or tor1Δ background may shed new light on the mechanism of enhanced longevity in these mutants.
Even though rotifers grow throughout their entire life cycle, the size increase illustrated here was independent of enhanced longevity.
Similar to OsTZF1, overexpression of AtTZF2/3 caused delayed senescence, enhanced longevity, and larger plants at the mature stage [ 15].
However, just like in the worm, we observed that RNAi-inactivation of certain ETC genes resulted in enhanced longevity [ 34].
The MOM Hip Resurfacing System has been proposed to have advantages such as enhanced longevity (Chan et al. 1999, Sieber et al. 1999, Firkins et al. 2001), enhanced implant fixation (Grigoris et al. 2006), lower dislocation rate (Scifert et al. 1998), better reproduction of hip mechanics, and more native femoral shaft bone stock left for revision surgery (Shimmin et al. 2008).
Interestingly, a previous study showing enhanced longevity of odor-stimulated adenovirus-infected olfactory neurons implicated CREB as the mediator of this effect (Watt et al., 2004).
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