Sentence examples for the enhanced affinity from inspiring English sources
It is postulated that the enhanced affinity of chromium for nitrogen leads to a reduced mobility inside the alloy, thus prohibiting a timely surface passivation.
The enhanced affinity afforded by AMP-PNP/Mn2+ may be a useful strategy for increasing affinity and trapping other protein substrates with their cognate protein kinase.
IL-7 binds glycosylated IL-7Rα 300-fold more tightly than unglycosylated IL-7Rα, and the enhanced affinity is attributed primarily to an accelerated on rate.
Yet in contrast, the enhanced affinity of the EuE-based inhibitors was associated with 1.4-fold and 2.7-fold higher internalization rates in PSMA-expressing cells in comparison to the reference ligands.
CK2-mediated phosphorylation increased SIRT1 interaction with unacetylated GST-p53 (Fig. 5, bottom), indicating that the acetyl-group on the substrate is not a feature that is required for the enhanced affinity.
The most drastic effect was observed in the case of mutants W377A and S404A with ∼10 times and ∼6 times reduction in their Km values signifying that substitution of residues Trp377 and Ser404 to alanine results in the enhanced affinity towards palmitic acid binding.
Finally, to elucidate the mechanism behind this enhanced affinity, we performed a series of control experiments with modified versions of ABA1 ABA65, and found that both aptamers make critical contributions in binding to Ang2.
The larger binding pocket on CL-K1 and the resulting enhanced affinity for its glycan ligands compared to other collectins suggest that it may be possible to design inhibitors that selectively block ligand binding.
To understand the origin of enhanced affinity by the addition of fluorine at the C5 position, we compared the binding affinity of 5-fluorouridine to other C5-substituted uridine analogs with differing electronegativities and atomic radii (Table 3).
Although the trivalent dendron showed enhanced affinity compared to that of the equivalent monovalent peptide, the higher valency generation 2 dendron had lower affinity for the integrin.
The data presented here reveal three distinct binding modes of the reaction analogues and demonstrate enhanced affinity in the K170M mutant.
