Since high ER activity can provide an escape pathway to reduce the efficacy of and cause de novo resistance to HER2-targeted therapies, we next asked whether up-regulated ER expression and/or activity might cause acquired resistance.
Calcein has also been previously utilized to evaluate the efficacy of peptides in causing membrane perturbation [50].
Yet Aristotelian accounts called for the efficacy of the causes, acting through the process of ensoulment.
Second, the principle is couched in terms which do not include locomotions: it is substantial, qualitative or quantitative form which is claimed to be transmitted through the efficacy of the cause in Physics 3.2, 202a9 12.
Despite these explicit confirmations of the efficacy of dependent causes (i.e., those that are other than God), it is difficult to avoid the conclusion that La Forge assumes a clear conception of how God's creative action operates, and that the sufficiency of God's causation makes the causation of natural events redundant.
But the government's long-standing lack of conviction about the efficacy of drugs still causes dismay.
When we monitored SGs and the efficacy of NH4Cl, which causes a buildup of LC3-positive autophagosomes, by immunofluorescence using antibodies for TIA-1 and LC3, respectively, we observed LC3 recruitment to SGs.
Without addressing that issue, La Forge argued that even radical dissimilarity could not constitute a valid objection in principle to the efficacy of a putative cause; otherwise God, the supreme cause of everything, could not cause creatures that are so dissimilar to his nature (T 213; THM 124).
In H460 mouse xenograft models, AZD7762 potentiated both the efficacy of gemcitabine and irinotecan, causing tumour growth delays of >10-fold and >3-fold, respectively.
Tijink et al (2006) have shown that the combination of I-L19-SIP with Cetuximab, an anti-EGFR antibody, enhanced the efficacy of the RIT without causing an increase in toxicity.
