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Due to a great availability of mutant strains it represents a standard method to analyze in vivo the effects of targeted gene manipulations.
The most plausible explanation may be that the effects of targeted chemotherapy within a few CRC patients do not always translate into a change in tumor size.
Direct evidence on the effects of targeted agents on bone metastases is currently limited to a few studies, which suggest that TKIs can extend the mean time to progression of existing bone lesions and reduce formation of new bone lesions2,76.
Selection of appropriate cell lines for in vitro analysis of the effects of targeted agents is a critical decision point.
Thus, we evaluated the effects of targeted delivery of SDF-1α using a pH-sensitive polymer poly (urethane amino sulfamethazine) (PUASM), a synthetic macromolecule with potential for targeted drug delivery in acidic conditions, to enhance therapeutic neurogenesis and angiogenesis in a rat model of permanent middle cerebral artery occlusion.
In this study we examined the effects of targeted TRPV4 activation on self-assembled articular cartilage constructs.
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We next studied the effects of targeting β4 in wounded HSEs, which faithfully recapitulate the keratinocyte migration and proliferation seen in cutaneous healing of wounds in vivo.
However, accumulating evidences demonstrate that the effects of targeting EGFR in colorectal cancer are largely limited due to the status of KRAS mutation [5].
Next, the effects of targeting cMET with INC280 on growth of pancreatic cancer cell lines were determined in vitro.
Histological analysis of the effects of targeting aurora kinase in melanoma tumours was performed on tissue microarrays (TMA).
We identified 18 randomised clinical trials comparing the effects of targeting intensive glycaemic control versus conventional glycaemic control.
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