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From an LETG perspective, the effects of concern are a degradation of the CCD energy resolution that is employed for order sorting, grade migration that can make for difficult calibration of detector quantum efficiency, and, at longer wavelengths (\mathrel > 50 Å), a loss of events that have pulse heights below that of the ACIS event lower level discriminator.
There are conflicting results about the perceptions of women, either optimistic or pessimistic, and the effects of concern and risk perception about cancer on their screening behaviors.
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In the case of polyols the effect of concern is digestive discomfort and this is related to the consumption of polyols in the short-term.
Similar to a MOA analysis, the first step in a Key Events Dose-Response Analysis (KEDRA) involves specifying the effect of concern for the agent of interest.
The effect of concern in our risk assessment is the most common effect of chronic ingestion of fluoride in the form of fluoride salts: dental fluorosis.
If these mechanisms fail (i.e., if control is lost), the pathogen has an opportunity to continue along the Key Events pathway toward the effect of concern.
While every event in the pathway must occur in order to achieve the effect of concern, it is conceivable that a particular event could disproportionately influence its likelihood.
It was proposed that this approach would give the best approximation to real exposures to polyols that are relevant to the effect of concern.
Figure 3 summarizes Key Events along the pathway from vitamin A intake to the effect of concern, which in this case is inappropriate gene expression.
Discuss what is known about dose-response and homeostatic mechanisms at each Key Event, including implications for the existence of thresholds at the event, and implications regarding the role of the event in protecting against the effect of concern.
As noted above, one of the first tasks in conducting a KEDRA is to describe the pathway of key events occurring between the initial exposure and the effect of concern.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com