Sentence examples for the effect of this mutation from inspiring English sources

In an attempt to dissect the mechanism of escape of the Nef TW9 mutation, we investigated the effect of this mutation on CTL recognition of CD4+T cells infected with an engineered SIVmac239 that contained the TW9 mutation in Nef.

We have examined the effect of this mutation on the structure and function of NCS-1.

However, the effect of this mutation is only intermediary as compared with AgmISG15 (see Figure 5b).

Based on molecular modeling, the effect of this mutation over protein stability is probably independent of p.D322G mutation found on the same allele.

The program replaces each of the interface residues with alanine residue and computes the effect of this mutation on the binding free energy of the complex.

Mutation of K99 to arginine would eliminate the preferential sites for both, sumoylation and ubiquitination, and we could then explore the effect of this mutation in USP25m activity directly on MyBPC1, a physiological substrate.

Both in vitro studies of recombinant mutant αB-crystallin and transgenic models expressing the mutant protein in vivo have contributed to our understanding of the effect of this mutation on protein function [27], [31] [33].

Future studies will focus on the effect of this mutation on immuno- and chemo-therapies to improve clinical diagnosis and treatment, and therefore predict the outcomes for patients suffering from hematopoietic malignant diseases such as ATL and CLL.

The central end of the present work is the detailed study of the BL phenotype to characterize the effects of this mutation, at organ and cellular levels, on both morphological and physiological traits.

We report the effects of this mutation on aggregation and biofilm formation in a model system.

We further investigated the effects of this mutation on the binding interactions of the mutant enzyme with the substrates.