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We used inhibitors of the ATM, ATR, Chk1 and Chk2 kinases to study the effect of replication and DNA damage checkpoints on the replication and repair of the psoralen ICL-containing plasmid.
Results reported herein pertain to the effect of replication within any given environment.
Therefore, the effect of replication selection is weaker than that in B. burgdorferi.
Because the effect of replication was not statistically significant, data were pooled before statistical analysis of treatment effects.
Similar(55)
The base composition skews in the coding sequences were used to derive quantitatively the effect of replication-driven mutation plus subsequent selection ('replication-associated pressure', RAP), and the effect of transcription-driven mutation plus subsequent selection at translation level ('transcription-associate pressure', TAP).
In explicitly considering this link it becomes essential to separate out the effects of competition from the effects of replication on the evolution of parasite life history traits.
The approach is extended to consider the effects of replication studies.
In this case, overexpression of factors such as Plk1 might drive DNA replication forward, overcoming the effects of replication stress.
The effects of replication origin proximity, replication polarity, and replication inhibition support replication-based models of TNR instability in mitotic cells [ 2- 9].
The concept of TRP was introduced by analogy to the PPV of diagnostic testing and extended to consider the effects of replication studies.
The effects of replication and mitotic recombination on GC content could thus locally interfere and reinforce or cancel out each other.
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