DOI: http://dx.doi.org/10.7554/eLife.03696.001 During the earliest phases of development, the embryo is formed by groups of stem cells that can develop into all the different types of tissue in the body from bones to brain tissue.
In the biopharmaceutical industry, more positive value may be created by drugs in the earliest phases of development, rather than the ones closer to FDA approval, and/or by failed drugs repurposed to another use (Beach, 2011).
He highlighted the importance of conducting extensive pharmacokinetic analyses during trials and of intensive characterization of drugs and their effects from the earliest phases of development.
We do not know whether Central Asia, the Near East and China were in contact in the earliest phases of development of grape culture, although there is evidence of wine making in these cultures around 7,000 BC [ 19].
Belimumab is a mAb against B-lymphocyte stimulator (BLyS) which was developed using this technology and is in the early phase of development for a number of rheumatic indications (Table 1).
Yabuki et al. [37] present a system in the early phase of development, aiming at supporting the collaboration between people working outdoor on environmental issues.
Manifold system properties with specific dependencies within the observed system necessitate a systematic analysis to facilitate a targeted consideration in the early phase of development.
In order to maximize the impact of research investment in a new bio-based chemical industry, there is a need for assessing the technological, economic, and environmental potentials of combinations of biomass feedstocks, biochemical products, bioprocess technologies, and metabolic engineering approaches in the early phase of development of cell factories.
Though these programs are still in the early phase of development, both CCA and real-time ridesharing provide a glimpse of a greener future for the energy and transportation sectors and build upon innovative ideas from Steve Jobs.
However, in the early phase of development, Ezh2 controls the formation of airways and is required for the full maturation of Sox2+ Scgb3airwayrway progenitor cells into club cells.
