The early large scale transcriptional profiling efforts provided the initial impetus for characterizing the phenotypic heterogeneity of cancer that allowed to discover transcriptionally-uniform cancer subtypes that were associated with distinct clinical outcomes [ 7, 8].
So, for sleaze appeal, they added a blue banner high up on the cover promising the low-down on "Sinatra and His 'Rat Pack.' " These are the earliest large-scale Warhol paintings to use existing tabloid headlines as a subject, and the last on the theme that he would do in a brushy, painterly style.
The theatre, designed by Giovanni Battista Aleotti and built in 1618 (but not used until 1628, to celebrate the marriage of a Medici daughter to a Farnese son), was the first proscenium theatre to be designed for movable scenery and is the earliest large-scale indoor theatrical facility to have survived.
They are the earliest large-scale seed remains found in Taiwan up to now.
The earliest large-scale application of monolithic, double-sided silicon strip detectors was in the BOL experiment around 1968 at IKO, now NIKHEF, in Amsterdam.
Laguna City and Sceneway Garden were the earliest large-scale private-housing estates built in Lam Tin.
The class was the earliest large-scale use of the 2-6-4 wheel arrangement in Britain.
If this is Æthelbald, it would make it the earliest large-scale pictorial representation of an English monarch.
The genocide in Lithuania is seen by some historians as one of the earliest large-scale implementations of the Final Solution, leading some scholars to express an opinion that the Holocaust began in Lithuania in the summer of 1941.
Three somatic, non-synonymous point mutations of TRKB have been reported in the early large-scale sequencing studies in human cancers: two in colorectal tumors, TRKBT695I and TRKBD751N [17], and one in a lung adenocarcinoma cell line, TRKBL138F [19].
