It has been noted that this approach has limitations in identifying (efficient) late-firing origins closely located to the other (efficient) early-firing origins [2], [4].
Given the deterioration of testicular function caused by varicoceles is progressive, the early and efficient evaluation of testicular damage would be of great importance for the future medical intervention in this population.
Thus, the early and efficient recognition and engulfment of apoptotic cells has been proposed to be necessary to induce tolerance to autoantigens.
To manipulate replication timing, a two-step method was used in order to create a clean deletion of the early and efficient origin, ARS607 (supplementary fig. S2).
One of the earliest, yet most efficient global sensitivity analysis methods is the variance-based Fourier amplitude sensitivity test (FAST) [ 26].
To test if disruption of an origin of replication can increase the local mutation rate in an early-replicating/low mutation rate region, the earliest and most efficient origin, ARS607, was deleted in strain GL·36, where the URA3 gene is located 3 kb away from the origin.
Thus, the expression kinetics of genes involved in cross-talk between innate and adaptive immunity over the first 8 weeks post-infection were consistent with early efficient control of infection in the lungs.
It is therefore a continuous challenge to communicate and implement plans in an early, efficient and reliable way within the team and to constantly keep track about tasks that are completed, postponed or that are about to be forgotten.
As described earlier, efficient lytic cycle gene expression is dependent upon the transactivating function of the VP16-induced complex that is formed by the structural tegument protein VP16, HCF-1 and Oct-1 (reviewed by Wysocka & Herr, 2003).
Early efficient antirheumatic treatment and tight follow-up have been a successful strategy to postpone disability.
