Sentence examples for the downstream changes from inspiring English sources

While proteomics data has provided important insights into the active effects of S-enantiomers, metabolomics may shed new light on the understanding of drug-cell interactions as it reveals the downstream changes of proteome.

The downstream changes were a suppressed NF-κB activity and activated p38 and JNK kinase cascades.

We verified that the inhibitor only partially compromised the downstream changes associated with Pol II engagement, although it almost completely blocked the changes covering the TATA and Inr elements (lanes 9 14).

The integration of GWAS data with studies that examine the downstream changes in the RNA, protein and metabolite state has the potential to reveal the perturbations in molecular networks that are associated with disease.

In this study we describe the targeted knockdown of 11 genes using siRNA in BMDMs and the downstream changes in gene expression caused by specific siRNA activity as measured using genome-wide, exon-level microarrays (for list of genes targeted see Table 1).

We focused not on the causative lesions per se but on the myriad downstream changes in gene expression associated with domestication.

Moreover, the finding of disynaptic projections from the STN to the cerebellar cortex in non-human primates (Bostan et al., 2010) opens the possibility that pathological activity in the basal ganglia produces downstream changes in the cerebellum and cerebellar thalamus (posterior VL).

However, we recognized that the complexity of possible downstream changes relies on the non-linear dynamics of biochemical reactions possibly leading to non-proportional change in the concentration of the final component [ 66].

However, these lesion studies are potentially confounded by demyelination of fibres passing through the lesion site, and the possibility of secondary, downstream changes in associated brain structures as a consequence of their chronic denervation following the lesion.

The significance of the order of events leading from heparan sulfate accumulation through to downstream changes in the levels of biomolecules within the cell and ultimately the (predominantly neuropathological) clinical symptoms is not well understood.

51 The order of events from heparan sulfate accumulation through downstream changes in the levels of other biomolecules within the cell and ultimately the clinical symptoms of MPS III, particularly with respect to CNS degeneration, is probably the least understood aspect.