Sentence examples for the downstream activity from inspiring English sources

Signalling continues through AKT, DOCK1 and RAS to sustain RAC1/CDC42 activity, which result in the downstream activity of p21 protein (CDC42/RAC -activated kinases (PAKs), mitogen-aCDC42/RAC -activatedses (Mkinases finally activation of JNK/PAKs

The RhoGTPase-activating domain in Myo9b inhibits Rho, reducing the downstream activity of ROCK (RhoKinase), thereby increasing MLC phosphatase activity, reducing MLC phosphorylation (Reinhard et al., 1995, Wirth et al., 1996), and, therefore, reducing actin stress fiber formation.

The purity and purification methods play important roles in the downstream activity of BE and its derivatives.

Our results demonstrated that melatonin, via its MT1 receptor, plays an inhibitory role in breast cancer cell invasion, possibly by specifically downregulating the p38 MAPK signaling pathway, and the downstream activity of MMP-2 and MMP-9.

Our results demonstrated that melatonin suppresses the in vitro invasive potential of breast cancer cells by altering the phosphorylation of p38 MAPK and the downstream activity of MMP-2 and MMP-9.

In rAAV vector we constructed, TRE and rtTA units of Tet gene regulation system were inserted inversely each other, to delete the downstream activity of the HSVtk gene by rtTA gene promoter through antisense suppression and subtraction.

The downstream activities of these factors contribute to pathology through recruitment and activation of inflammatory cells, positive feedback of the IL-17 response, and destruction of tissue and bone.

And the extracted features and their related technical information and knowledge are encapsulated together with the geometry-oriented CAD model to form an integrated product information model to facilitate effective integration with the downstream activities.

The identification of the design features and their further decomposition into machining features for the downstream activities from a data exchanged part model is a bottleneck in integrated product and process design and development.

Furthermore, the following facts are required to move the sector forward: (1) a total restructuring of the hydrocarbon sector, (2) increase in PPs production, (3) rationalization of the decision-making mechanism by separating the different roles of NNPC, (4) privatization of the downstream activities of NNPC and (5) promotion of local contents.

In 1996 Gandur made the salmon leap from the downstream activities of oil trading and marketing, which provide thin margins by moving huge volumes of other people's oil, into the upstream, which entails more risk and upfront investment but offers fatter returns.