Sentence examples for the downstream actions from inspiring English sources
We have shown previously that reactive stroma promotes prostate cancer progression via induction of angiogenesis and the downstream actions of TGF-β1 induced factors in reactive stroma including connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) [18] [19], [19].
Irrespective of the cellular source, receptor blockade would abrogate the downstream actions of GM-CSF and may be a viable therapeutic option in treatment-resistant JIA.
The downstream actions of Akt include the phosphorylation of proteins involved in the apoptotic cascade and regulation of the expression of apoptotic proteins [ 23].
The key roles proposed for PKD activity in cardiac (patho physiology make improved understanding of the molecular mechanisms underlying both the upstream regulation and the downstream actions of this kinase in the heart an imperative.
For example, 7KC and 7βOHC inhibit 11βHSD1 activity in mouse adipocyte (3T3-L1 and 3T3-F442) celinesnes [20] and in differentiated human THP-1 macrophages [21], modulating the downstream actions of glucocorticoids.
Each block both the production of and the downstream action of the critical intermediate granulocyte-macrophage colony-stimulating factor.
These members are involved in the downstream action by cisplatin.
Inhibition of the downstream action of these angiogenic receptors has been shown to induce endothelial cell apoptosis [ 9, 20].
A benefit in developing imaging agents targeting over-expressed receptors is that the downstream action of the targeted receptor need not correspond to specific tumorigenesis mechanisms.
The results of this study further indicate that multiple molecular mechanisms must underlie the downstream action of apo-RARα1 on target genes in the context of mediating the effects of apo-ER.
We suspect our new findings reflect that both UNG‐ and SMUG1‐initiated switching can be facilitated by the downstream action of MSH2, with the SMUG1‐pathway being especially sensitive to loss of MSH2 (whereas UNG can lead to robust MSH2‐independent switching).
