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Six studies calculated daily dose by weight [29, 31 33, 39, 40], five studies calculated daily dose by basal energy expenditure (BEE) and the Harris Benedict equation [28, 30, 35 37], and five studies administered a fixed daily dose [25, 34, 38, 41, 42]; in one study [43], the dosing method was not specified.
However, for a specific drug the precision values were very close to each other, regardless of the dosing method used, which is a consequence of the very similar interindividual variability in clearance expressed in L h−1 m−2 compared with values expressed in L h−1 (Table 1).
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Although there have been no direct comparisons of these agents, sufficient clinical data have accumulated for investigators and clinicians to gauge the efficacy and safety of all three TNF antagonists and to assess the dosing methods and schedules.
Nevertheless, the question concerning the efficiency of this dosing method to evaluate the accumulation of active metabolites and their potential toxicity remains unanswered.
A low dose of antidepressant was selected because we sought to evaluate the usefulness of this dosing method at the lowest possible dosage limit which is used in other means of drug administration and because imipramine may exert side-effects when applied in higher concentrations [ 6].
17 Although individualized docetaxel dosing was feasible in both trials, they were not able to evaluate the efficacy of this dosing method due to the small sample size.
The latter dosing method approximately doubled the lifespan of all systems suggesting the influence of climate conditions on clogging.
This research has shown the ALI dosing method to be effective at delivering microgram quantities of nanoparticles to the cell surface within a few hours.
Further increases in yield might be achieved by optimizing the concentration and dosing method of the inducer and the timing of induction.
In this respect, the low-dose method presented by the authors could be an important staging method for XFEL experiments, and the combination of both experiments could be very powerful.
The FSR was evaluated using the flooding dose method as described by Garlick and McNurlan (1998).
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