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By extension to the field of clinical research, the concept of delivery of the intervention was called the "dose intervention" [ 25].
Finally, the principle of having a precise protocol for assessment and intervention appears to influence the outcomes [ 15, 25] by moderating the dose intervention or dose response.
Beyond the dose intervention issue, which explains much of the effect of variations in generalization, Victora et al. also pointed out the variability in an intervention's effect even with identical implementation [ 25].
We are also interested in the dose intervention participants receive, and define 'full' exposure to the intervention as being present at 17– 24 individual course sessions, moderate exposure as being present at 9 –16 components, and non-exposure as being present at eight or fewer components.
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There were a total of six deaths during the trial; none in the medium dose intervention group, 4 in the low dose intervention group and 2 in controls (P for controls vs treatment groups combined P = 0.65).
The dialysis dose intervention is directed by the Data Coordinating Center using urea kinetic modeling programs that analyze results from dialysis treatments to monitor adherence to the study targets, adjust suggested dialysis prescriptions, and assist in trouble-shooting problems with the delivery of dialysis.
One possible explanation for our finding is that the overweight/obese patients had worse adherence to the higher-dose exercise interventions (about 65%) compared with the standard dose intervention (about 80%) (Courneya et al, 2014b).
However, serum zinc level was significantly higher in participants receiving the medium dose intervention (50 mg/d) vs control at 90 and 180 days (1032 vs 932 ug/L, P = 0.04; 1036 vs 972 ug/L, P = 0.04).
Mean serum selenium concentration was significantly higher in participants receiving the medium dose intervention (75 mcg/d) at 90 days (146 vs 131 ug/L, P < 0.001) and at 180 days (139 vs 135 ug/L, P = 0.03).
The controversial findings could be explained by the low n-3 HPUFA dose intervention and the kinetics of dietary EPA and DHA and/or the participants' metabolism.
The dose delivered (intervention components), completeness of intervention components, and fidelity of implementation will be recorded by qualitative (site visits) and quantitative (logbooks, checklists) methods.
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