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This activity is depending on the dose and time of exposure (Fig. 2).
There was a significant effect of the dose and time of injection of PMSG on all parameters, except on the diameter of each dominant follicle and corpus luteum.
Both responses to secondary metabolism elicitation and growth reduction caused by physical elicitors widely vary depending on the dose and time of exposure (Dewir et al. 2010; Kováčik et al. 2009).
Therefore, safety protocols have been designed that allow thromboprophylaxis to be administered with optimal effectiveness and anesthetic techniques to be performed with maximal safety; these protocols are based on the drug used, as well as on the dose and time of administration.
Our results are in agreement with previous works, although the magnitude of the response was dependent on the dose and time of exposure to the pollutants [29], [31], [62].
The dose and time of infection were based on previous report by our group [ 12].
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We did not have complete data on the doses and time of administration of medications.
In this study, we found that female C3H mice do not show any evidence of arsenic-induced major clinical biological changes at the doses and time of exposure used in this experiment but do show changes at the genomic level.
These data indicate that the treatments with ISA27 and SM13 had no effects on mice health at the doses and time of treatment that were used in this study.
The dose and time course of activation of caspases 3, 9 and 7 (Figure 1B) paralleled the progressive loss of BAG3 (Figure 1E).
The dose and time dependency of the niclosamide response of JJN3, U266 and H929 cells are shown in Figure 1c.
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