Exact(34)
The DKK family comprises four members (DKK-1 to DKK-4) in mammals [ 33, 34].
The Dkk class inhibits canonical Wnt signaling by binding to LRP5/LRP6 of the Wnt receptor complex [41].
Hence, the expression profile of the DKK family observed here is suggested to be specific to EFT.
The canonical Wnt pathway is inhibited by Dickkopf-1 (Dkk-1), a member of the Dkk family of secreted Wnt antagonists [31].
In Xenopus and in mammals, the Dkk family includes Dkk1, Dkk2, Dkk3 and Dkk4, which exhibit distinct expression patterns and properties [9], [10].
Dickkopf 1 (Dkk1) is a secreted glycoprotein belonging to the Dkk family, which consists of four members (Dkk-1, -2, -3, -4).
Similar(26)
Furthermore, the DKK-1-treated lung explants from E11.5 mice showed impaired branching, failed cleft formation, and enlarged terminal buds with fibronectin deposition [36].
Moreover, we could speculate that CaP cells stimulate bone marrow environment to increase the DKK-1 release through unknown mechanisms.
We then examined the Dkk-1 response to chronic stress in the hippocampus of the two strains of mice.
The Dkk-1 gene promoter contains at least three glucocorticoid-responsive elements (GREs), and the GR agonist, dexamethasone, enhances Dkk-1 gene expression in human osteoblasts [51].
IL-7 and β-Actin specific TaqMan probes were previously used [18], while the DKK-1 probe was (5'-ATGCGTCACGCTATGTGCTGCC-3').
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