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A statistical design of experiments was used for the robustness evaluation of both the dissolution method and the HPLC analysis method.
Overall, standard dissolution methods can be adapted for a variety of formulation types, and previous studies have shown that dosage form presentation to the dissolution method chosen is a key component in determining reproducibility.
Due to the complex nature of the presented apparatus, any modification of the dissolution method can be easily performed.
Nevertheless, the dissolution method was developed as a universal, most physiologically relevant simulation of fasted state, and as such it provided results beyond expectation.
If the dissolution method has not been finalized, then dissolution profiles should be generated in at least three media (e.g., pH 1.2, 4.5, and 6.8).
In theory, this can be regarded as an inverse proportion between the sophistication of numerical procedures necessary for IVIVC/IVIVR and the degree of faithful representation of biological processes by the dissolution method.
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The accuracy of the selective dissolution method can be increased by consideration of the dissolution behaviour of the respective aggregate.
In addition, silk fibroin films prepared by this dissolution method had higher breaking strength and extension at break.
When the selective dissolution method is used, the reaction degrees of slag and fly ash may be overestimated at early age due to the loss of the superfine particles through the filtration and the partial dissolution of slag or fly ash, and underestimated at later age owing to the presence of cement and hydration products.
It is possible to use f 2 when the study materials being compared are of the same age (shelf-life) and if the same dissolution method (and detection method) is being used for the analysis, for example, comparing batches that have been manufactured after a process change with product batches that were submitted in an approval.
The metallic porous materials have been fabricated from the phase separating Fe Cu and Co Cu binary alloys on the calculated critical composition by the selective dissolution method.
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