They charted the discovery of new classes of animals since 1750.
Nitrogen mustard became a model for the discovery of other classes of anticancer drugs, and chemotherapy went on to become a standard treatment for many cancers, often in combination with surgery and radiation.
Recent breakthroughs in next-generation sequencing technologies have led to the discovery of several classes of non-coding RNAs (ncRNAs).
The rapid development and spread of bacterial resistance and the emergence of multi-drug resistant pathogens have created a need for the discovery of new classes of antimicrobial agents against novel microbial targets while evading existing resistance mechanisms.
Despite the many antimicrobial and chemotherapeutic agents are available in market, the emergence of old and new antibiotic resistant bacterial species in the last decade lead to a substantial need for the discovery of new classes of antimicrobial compounds [1].
In spite of all these advances, the human observer still plays an important role in the discovery of new classes of bioimaging probes [27, 29] because ultimately, staining patterns have to be recognizable, interpretable and mechanistically meaningful to the human eye.
Due to its high diversity, an environmental survey of the genes encoding putative WS/DGAT enzymes might allow a greater resolution for the discovery of new classes of WS/TAG-synthesizing acyltransferases with interesting biotechnological properties, in comparison to those already known from previous physiological studies.
Small RNAs are important regulators of gene expression, and recent advances in sequencing and bioinformatics techniques have stimulated the discovery of new classes of small RNAs.
DHS regions are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions.
The ncRNA revolution, which caught all of us unprepared, is ongoing, with the discovery of new classes such as long ncRNAs.
