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Since the DNA-damaging treatment we applied was proven to kill predominantly cells in S-phase [39] the diminished fraction of cells replicating DNA resulting from G1 accumulation would lead to the chemoresistance of the non-replicating cell population.
Moreover, the decrease in gained spines is morphologically reflected in the diminished fraction of thin spines, which commonly correspond to non-synaptic transient precursors of the larger established spines [ 39, 40].
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The reduction of the emeraldine form by hydroquinone was observed after a positive potential switch, resulting in a diminished fraction of the emeraldine form in the polymer film at a quasiequilibrium state during electrolysis.
In therapeutics, a small fraction of the therapeutic dose will not necessarily produce a moderate or full response in a diminished fraction of the treated population.
This ectopic expression strongly enhanced the rate of internalization after EGF stimulus, which was concurrent with a diminished fraction of recycling EGF-EGFR.
Consistently, knockdown of Smad7 associates with inactivation of eIF2 α, lower CDC25A expression and diminished fraction of proliferating cells in human CRC explants, and reduces the number of intestinal tumors in Apcmin/+ mice.
We observed a continuous decrease in spine density during disease progression, which we could ascribe to a diminished fraction of gained spines.
Changes in the total number of spines such as a reduced spine density can therefore result from either a loss of persistent spines, a diminished fraction of new spines or an enhanced fraction of retracted spines.
The main novel finding in this study was the diminished transfer of unesterified cholesterol to the HDL fraction in T2DM + CAD, despite the fact that the HDL-cholesterol and apo A-I concentrations were equal in both groups.
Why the diminished footprint?
"The diminished revenue was startling.
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