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This method has several drawbacks, such as the difficulty to assess small failure probabilities and its inability to parallelize computations.
Biological monitoring of human exposure to environmental pollutants is hampered by the difficulty to assess data reliability.
The main reason for that is the lack of standardized tests and the difficulty to assess direct shear in fiber reinforced concrete (FRC) both for the design and for the quality control.
The difficulty to assess conscious perception in controlled experiments, in particular, gave rise to endless methodological discussions as to the best approach to consciousness, and what counts as index of conscious experience – e.g., direct vs. indirect, objective vs. subjective measures [18], [25], [36].
Detection of IFN type I activity is hampered by the difficulty to assess the different subtypes of this cytokine.
The neurological component of SOFA was left out because of the difficulty to assess the actual Glasgow Coma Scale in sedated patients.
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However, we are aware of the difficulties to assess the function of the coagulation system "ex vivo".
The proxy-report was chosen due to the difficulties to assess self-report in most of these children.
When delimiting species in phylogenetic placements, which requires calibrating thousands of trees, it is almost impossible to deploy these methods in an automated pipeline, given the difficulties to assess MCMC chain convergence, for instance.
We investigated a large control population and the apparent finding of a large 3p14.1p13 deletion in this cohort affecting FOXP1 and further genes illustrates the difficulties to assess the significance of rare mutational events in extremely heterogeneous diseases and may point to incomplete penetrance.
In fact, the heterogeneous clinical spectrum of the disease with a potential predominant pattern of the skin, nail and articular involvements should be taken into account for the pharmaco-economic evaluations, since the difficulties to assess these components by the actual outcome measures [ 20- 22].
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