Graham replied to Findlay regretting that "although we have been engaged in this sort of investigation for the past few years, we do not think that, at present, much help has been given to the clinician"—but the reason he gives for this ("mainly because of the difficulty of the laboratory methods involved") indicates that they are beginning to shift away from Findlay's position.
However, the difficulty of this method is the variations in sympathetic responses to low temperature in different rats, reducing the reliability of the imaging method.
The difficulty of this method is really low, nevertheless the graphene flakes require to be found on the substrate surface, which is labor exhaustive.
The difficulty of this method is that the required data are very diverse and are not in one archive.
Our estimated K+ flux is several times greater than the maximum rates measured by Messerli et al. (1999), perhaps due to the difficulty of the vibrating electrode method.
In the equivalent systems, the number of terms frequently increases (see Additional file 3), and this may result in the difficulty of the application of our method to a complex or large model.
This work overcomes the difficulty of the previous matched interface and boundary (MIB) method in dealing with interfaces with non-constant curvatures for optical waveguide analysis.
More attention needs to be given to creating a fully integrated design loop of digital architecture, where the gap between form in the virtual model and physical model is generally larger than it was in the pre-digital era due to the difficulty of the externalization of challenging forms via traditional methods.
We also were interested determine to what extent the cross-validation classification performance is influenced by different data-resampling methods and the difficulty of the classification problem.
Regarding the clinical use of the GIR, a majority of the participants are in favour, as is shown in Table 2. However several participants mention more negative aspects, such as the difficulty of applying the method in the clinic, and the difficulty of accurately predicting the risk of rejection.
