Sentence examples for the difficulty of optimizing from inspiring English sources

The difficulty of optimizing Reinitz models of transcription does not mean that the (sub-optimally) optimized models provide biological meaningless predictions.

Our work underscores the value of exploring water-mediated interactions to study ligand binding, and highlights the difficulty of optimizing polar interactions due to high desolvation penalties.

However, several previous attempts to use the GPU for accelerating MC simulations have shown limited success, probably due to the difficulty of optimizing the GPU code for high performance.

However, several previous attempts to use the GPU for accelerating MC simulations by other groups have shown limited success due to the difficulty of optimizing the GPU code for high performance.

The mutations that generated a higher-stability variant of SA were in the second shell of residues around biotin, pointing to the difficulty of optimizing this kind of high-affinity interaction computationally.

The N-queens problem is an interesting application for testing the accuracy of genetic algorithms due to the inherent difficulty of optimizing the problem under efficient time and memory constraints.

Ductility and electrical conductivity of metallic materials are inversely correlated with their strength, resulting in a difficulty of optimizing all three simultaneously.

The cost results from the difficulty of having to optimize many phenotypes simultaneously and it is manifested by the decreasing fraction of beneficial mutations as dimensionality increases [ 11, 13, 15, 21].

Facing the difficulty to optimize such nonorthogonal and nonlinear transforms, we implement a sparse approximation scheme inspired from the functional architecture of the primary visual cortex.

Critically ill patients are at risk of energy deficit during their ICU stay, a condition which leads to unfavorable outcomes, due to hypercatabolism secondary to the stress response and the difficulty to optimize feeding.

For a proof of concept of the difficulties of global optimizing non-linear models and of the use of recasting for attaining practical solutions, we shall start by defining a reference biochemical network that corresponds to the reaction scheme in Figure 1.