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Thus, the difficulty of developing the system via the formulation of a single optimization problem in which the optimal synthesis/design and operation/control of the system are achieved simultaneously is great and rather problematic.
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Early challenges in the policy development process included the difficulty of developing consensus around the definition of professional support options that would be included, the selection of activities for inclusion, and the establishment of minimum standards across a diverse workforce.
But another important reason may be the difficulty of developing reliable metrics to measure the performances of employees who work at home, especially when they are involved in team projects.
This approach would avoid the difficulty of developing one giant ship with equipment and supplies for a round trip.
One of the factors contributing to the reinforcement of dominant firms and silos is the difficulty of developing and integrating internet of things applications.
Despite the difficulty of developing games in public, he tells me he would still Kickstart future releases: "Because you don't just get support, you get emotional support".
The secretin story shines a light on the difficulty of developing a drug for autism, an often debilitating condition whose incidence seems to be rising sharply and for which there are no approved drugs.
On one such site, monitored by the Customs Service, some 3.2m images of sexually exploited children were downloaded in one month in 1999.The ubiquity of computers and the difficulty of developing "filters" that skim off offensive material without restricting access to the useful sort make web-policing a formidable job.
The difficulty of developing suitable problem definitions potentially limits the use of automated process design tools.
The complicated biaxial hysteretic loops confirm the difficulty of developing suitable load-displacement models for non-linear dynamic analysis.
The difficulty of developing such complex systems has been limiting the clinical translation of new methods and ideas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com