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The difficulty of Computational Wind Engineering (hereafter CWE) is described from the viewpoints of Computational Fluid Dynamics (hereafter CFD) technique.
First, the difficulty of computational prediction of subcellular localization is well recognized (Lei and Dai 2005; Chou and Shen 2007).
Because of the difficulty of computational searches for sRNA binding sites [ 42], we restricted this search to pXO1 (NC_007322), which is where the putative sRNA genes were located.
Also, the molecule (in addition to the protein) undergoes conformational changes, underscoring the difficulty of computational methods to model such interactions.
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Moreover, we suggest a greedy algorithm to decompose a camera motion trajectory into a more compact set of slices and fibers, and together with the efficient convolution computation via fast Fourier transform (FFT), the proposed GAC models concurrently overcome the difficulties of computational cost and memory burden, leading to efficient GAC-based deblurring methods.
According to Deutsch, the insight for that paper came from a conversation in the early eighties with the physicist Charles Bennett, of I.B.M., about computational-complexity theory, at the time a sexy new field that investigated the difficulty of a computational task.
However, it is generally true that the difficulty of producing highly accurate computational models can be significant, and is counterintuitive in regard to the inherently poor resolution of DOT.
This article investigates the difficulty of resonance assignment, using a computational Monte Carlo/simulated annealing (MCSA) algorithm to search for assignments from artificial three-dimensional spectra that are constructed from the reported isotropic 15N and 13C chemical shifts of two proteins whose structures have been determined by solution NMR methods.
Proteins have a high tendency to assemble secondary structures consecutively, which lowers the difficulty of predicting the protein structure by computational means.
However, this method adapts poorly to other platforms such as the Illumina and Ion Torrent, due to a much larger amount of data produced, which increases both the computational complexity, and the difficulty of merging divergent genotypes and handling process error.
Computational tests are conducted to analyze the difficulty of solving several variations of the problem.
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CEO of Professional Science Editing for Scientists @ prosciediting.com