A decade ago editorial attention in the Lancet was paid to the conceptual and methodological difficulties pertaining to the concept of QoL [ 13].
To overcome difficulties pertaining to the imbalance in the tumor cell apoptotic pathway, we therapeutically targeted cells that present normal levels of the BCL-2 relatives, the endothelial cells.
Being a 'difficult patient' is further dependent on a spectrum of difficulties pertaining to the patient himself, such as poor illness perception and understanding (resulting in undertreatment or overtreatment), smoking habits/lifestyle/behaviour, poor intelligence, poor compliance, old age and bad quality of life/poor economy.
Cognitive interviews can indicate the existence of problems with questions, for example, difficulties pertaining to a particular recall period or to the mode of administration.
Searching for such loci systematically at a genome-wide level will require extremely large-scale sequencing, for which the technology is currently being developed and which will present us with new statistical challenges and methodological difficulties pertaining, for example, to the functional study and classification of identified variants.
Until recently, limited information has been available regarding mechanisms modulating miRNA expression during malignant transformation, primarily due to difficulties pertaining to identification of promoters and transcription start sites (TSS).
In addition to these four variables, difficulties pertaining to substance use, family and marital relationships, education and/or employment, and leisure activities make up the "Central Eight" variables that are implicated in criminal offending behavior according to the GPCSL perspectives (Andrews & Bonta, 2010).
Responders rate the level of difficulty pertaining to each item on a 5-point Likert response format, generating summative scores for each domain.
A difficulty pertaining to theories of coherence that construe coherence as a multidimensional concept is to specify how the different dimensions are to be amalgamated so as to produce an overall coherence judgment.
Written in January 1970, when Adams would have been 17, the poem is entitled "A Dissertation on the task of writing a poem on a candle and an account of some of the difficulties thereto pertaining", and stretches to two pages.
