These include inter alia the necessity of patient group matching to ensure valid comparative conclusions and the difficulties of time-consuming conduction of longitudinal studies [ 7, 8, 24].
With the transition of design method from traditional frequency domain approaches to more refined direct time domain approaches, the difficulty of time integration of these systems occurs sometimes.
They even talk about the difficulties the Founders had grappling with these ideals during the difficulties of their time -- including holding the natural rights of humanity aloft, while nearly tearing themselves apart over the issues of slavery.
While acknowledging the difficulties of quantifying time preferences and warning that considerable uncertainties surrounded their calculations, they concluded that tobacco excise rates could be increased substantially in Australia.
In fact, 11 days ago President Bush acknowledged the difficulties of these times and the special needs of a divided nation.
This shows me how they survived the difficulties of their times and teaches me how to survive as a native person today.
Under Marcus Aurelius, the difficulties of the times often caused the Christians, who refused to sacrifice to the state gods and to participate in the imperial cult, to be accused of provoking the wrath of the gods: martyrs appeared in the East, in Rome, in Gaul, and in Africa.
Though Billington said that Levine's background and subject matter were not factors in his selection, they do help in making the case for poetry's relevance to the difficulties of the present time: high unemployment and a faltering economy.
The human impulses of trade and exchange, of cultural piggybacking, were, for all the difficulties of travel and time, strong enough to blend tribes and groups and peoples as varied as any we know now.
A finite difference method is developed which overcomes the difficulties of the disparate time scales and small solute diffusion layers inherent to one-dimensional models for the solidification of binary alloys.
