All these difficulties notwithstanding, it seems that we have identified a parameter that may be associated with cetuximab clinical benefit.
53 These difficulties notwithstanding, it would be immensely valuable to identify bone change-related genes because many may fall in pathways that are more amenable to therapeutic modification than pathways specific for bone acquisition.
These limitations and difficulties notwithstanding, the value of paired genomic and epigenetic centromere datasets has been amply demonstrated in studies from human, plant, and Drosophila genomes that have been valuable for defining current models of centromere specification, identity and function [ 9, 11, 20, 24, 31, 33].
Giles' notion of quantitas materiae, which is not only generically extension or three-dimensionality, but seems to represent an unchangeable given "amount" of matter pertaining to a body, has been considered comparable, some difficulties notwithstanding, to the modern notion of mass (Donati 1988).
These difficulties notwithstanding, it is apparent that CAM use continues to be significant.
These difficulties notwithstanding, control selection needs to focus on endometriosis-free women who are representative of the population from which cases are drawn.
Hoppe said, "Notwithstanding the difficulties in negotiating while there is litigation, SMG would be willing to negotiate with a party that has the wherewithal to buy the team".
Notwithstanding the difficulties in the design process, we're prepared to compensate Libeskind fully for the time that he and his staff put onto working on the Freedom Tower".
Notwithstanding the difficulties in defining and measuring quality in HE, there does not appear to be any empirical evidence that supports the assertion that the use of digital technologies improves quality; indeed there are indications that if poorly implemented, they may instead have a detrimental impact on students' learning.
Notwithstanding the difficulties in assessing the extent to which the on-going dwindling of foreign exchange reserves will result in individual emerging economies becoming too vulnerable, one can expect a relative weakening vis-à-vis the ascent phase until mid-2014.
Notwithstanding the difficulties of teasing apart population size and selection effects on rates of evolution (see above), this is most likely due to the relatively small number of mutational events that occur between closely related samples, making it difficult to achieve a statistically significant number of nucleotide mutations between sequences.
