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Thus, natural history is partly covered by the differing trial durations of the studies analyzed.
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Yet if the decision process differs on different trials, we may miss the very events that would be most enlightening.
First, the characteristics of study populations differed between the different clinical trials that were carried out.
The sample and the choices differed from trial to trial, and the location of the correct target varied randomly between the upper or lower position from trial to trial as well.
By contrast, randomised controlled trials may have poor generalisability when the patients in the trial differ from those who would receive the intervention routinely.
However, the reasons for enjoying the trial differed between the sites.
The two arms of the trial differed in two ways with regard to QL.
Additionally, we ran a one-way repeated measures ANOVA to assess if the performance differed between trials in which no modification, only causally relevant, only causally irrelevant or both types of modifications occurred.
The question arises why the model outcomes differ from the trial results.
If, for example, the HR is diminishing over time, the procedure will over-estimate the HR whenever the trials differ in follow-up time.
Cases where the actual number of patients recruited in the trial differs from the preplanned sample size are also considered.
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