The results of the present study indicate that chicken PTH1R and PTH3R are functionally different and this observation with the differing tissue expression supports the idea of differential cellular functions.
Additionally, discrepancy could be due to the differing tissue histology of the prostate and therefore possible differing purity for stromal vs. luminal cell types.
A noticeable body of research reported detection of pathology within the neurological system based on the differing tissue characters in T1-weighted and T2-weighted MR images [ 1, 2].
In our analysis we selected 20 FFPE blocks from 2008 from a single pathology department, in order to reduce the chance of failure due to the age of the tissue block or differing tissue processing methods.
Thyroid hormones act via nuclear receptors (TRα1, TRβ1, TRβ2) with differing tissue distribution; the role of α2 protein, derived from the same gene locus as TRα1, is unclear.
Confocal images comparable to standard pathological sections were taken from the same piece of tissue, but not necessarily of the identical field because of differing tissue orientation and sectioning depth.
Therefore, the site and specific tissue of origin are important in determining karyotypic patterns of cancer cell so that similar aneusomic chromosomes can demonstrate different patterns of gene expression in differing tissue contexts.
The development of optimal SERMs for the prevention and treatment of breast cancer, and for hormone replacement therapy and fertility regulation, can now be viewed in the context of two estrogen receptor subtypes, ERα and ERβ, that have differing affinities and responsiveness to various SERMs, and differing tissue distribution and effectiveness at different gene regulatory sites.
56 Moreover, the discovery of multiple ERβ various isoforms (β1, β2, β4, and β5) with differing tissue distribution and function further adds to the alternative results of ER stimulation.
Each gene undergoes alternate splicing to generate TRα1, TRα2, TRβ1 and TRβ2 isoforms, each with differing tissue distributions (e.g. TRα1 is the predominant isoform in the central nervous system, myocardium, colon and skeletal muscle; TRβ1 is highly expressed in the liver and kidney; TRβ2 plays a major role in negative feedback regulation at the level of the hypothalamus and pituitary) [6].
This prediction necessitates a large family of related sugar transporters, with differing tissue expression patterns, and importantly subtle differences in substrate affinity between transporters.
