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As a test of concept, this proposed neurodegenerative process might be investigated clinically by taking advantage of the differing actions of the cholinesterase inhibitors that are widely used in the hope of achieving symptomatic benefits for AD patients.
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The differing mechanistic actions of these drugs can lead to differences in ADC response.
These findings suggest that the relationships among the concentrations of the four metals in food and feces are almost equal to each other, but differ greatly from the concentrations in human organs due to the differing metabolic actions of the metals once they are absorbed into the body.
These will be the first head-to-head trials using carvedilol CR to determine whether the differing pharmacologic actions among β-blockers result in varying effects on cardiovascular risk factors.
These differing actions were mediated by Ca2+ changes involving IP3 receptors and/or TRP channels [33].
Daily transanal administration of 0.1% freeze-dried L. brevis culture in saline decreased DSS-induced intestinal inflammation, improved survival, and decreased expression of TNF- α, IL-12, and IL-1 β [ 72], highlighting the importance of identifying the differing mechanisms of action of different Lactobacilli.
To summarize, the thermal research showed that the difference between standard RFA and innovated IRE with the balloon catheter lies not just in the differing mechanism of action, as is well known, but also in its thermal effects.
The differing mechanisms of action and areas of efficacy of these 2 drug classes make them promising candidates for combination therapy.
We feel that the therapeutic effects resulting from the differing mechanisms of action of aspirin and cilostazol have not been sufficiently investigated in this patient population.
The differing mechanisms of action, and relative nonoverlapping toxicities compared with PF, have prompted interest in the addition of docetaxel to PF regimens.
The differing mode of action and toxicity profile of gemcitabine and marimastat make the combination of these agents an obvious therapeutic strategy to investigate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com