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This can be done by coarsened exact matching (CEM) where the reweighing is done individually on the different confounders depending on relevance10.
Table 4 shows the contribution of the different confounders to the outcome depression, crude and adjusted.
Each potential confounder was considered separately in the models to take account of the impact of changing sample sizes because of missing data for the different confounders assessed.
In the Cox regression models with follow-up time as time scale, the associations of copeptin with CV and all-cause mortality remained significant after adjustment for the different confounders (Table 3).
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Our overall findings also were robust to various modeling strategies, including the use of different confounders and the use of fixed effects for each subject.
Third, we extracted the risk estimates that reflected the greatest degree of the control potential confounders, the results based on the adjustment for different confounders were probably different from those based on standardized adjustments.
A multivariate analysis ruled out the role of different confounders in our results, including gender, use of preventive therapy, and migraine comorbidities such as anxiety or depression.
Some heterogeneity of effects between our results and what was reported in the original papers might be expected, as they could be driven by potential differences in the normalization pipeline of the array data or by the correction of the methylation values using different confounders.
Because the ORs in the five studies were adjusted by different confounders with different regression models and the data reported on adjusted ORs were limited, we thus adopted unadjusted mortality data for pooled analyses in the present study.
A multivariate binary logistic regression model was applied to test the independent role of different confounders.
This could be due to many different confounders or cultural differences between the two populations.
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