Estrogens stimulate the development of secondary sex characteristics and the maturation of ovarian follicles.
In rare instances prolonged use of anticancer drugs can lead to the development of secondary cancers.
Metastasis, migration and spread of cancerous cells from a tumour to distant sites in the body, resulting in the development of secondary tumours.
They are responsible for the development of secondary sex characteristics growth of pubic and axillary hair, pigmentation of the nipples and genitals and contribute to bone formation.
Furthermore, limb realignment in these pathological conditions prevents or slows down the development of secondary osteoarthritis.
Environmental factors, irrespective of age and sex contribute for the development of secondary osteoporosis.
Becker et al. also postulated that these patients might be prone to the development of secondary spontaneous pneumothoraxes [11].
Arabidopsis thaliana provides a good model for investigating the development of secondary xylem (Turner et al. [2007]).
Therefore, groundwater occurrence is associated with the development of secondary porosity as a result of jointing, shearing, fracturing and weathering.
Cerebral edema (CE) is the key factor for the development of secondary brain injuries after severe traumatic brain injury (TBI).
The development of secondary lymphoid tissues (e.g., spleen, lymph nodes, and Peyer's patches) starts at week 8 of gestation [8].
