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One possible mechanism for extra-neuronal and extra-lymphatic deposition of prions may be linked to the secondary inflammatory conditions of organs, leading to the development of isolated lymphoid follicles [12].
In their article, Pierik et al. (2004) proposed multiple possible maternal and paternal risk factors related to the development of isolated hypospadias, including genetic, endocrine, and environmental factors.
A decrease in vascular compliance, such as what occurs with aging in larger blood vessels such as the aorta, may also contribute to the development of isolated systolic hypertension.
HRT was suggested to exert protective effects against the development of isolated pulmonary hypertension in patients with SSc and limited cutaneous involvement [ 9], while tamoxifen did not improve SSc symptoms [ 10].
A common pathway, by which insulin resistance leads to increased cardiovascular risk, is increased arterial stiffness, which is directly linked to the development of isolated systolic hypertension, increase in cardiac afterload and finally impairment of coronary perfusion [ 3].
OBJECTIVE The aim of this study was to describe the natural history of insulin secretion and insulin sensitivity in the development of isolated impaired fasting glycemia (i-IFG), isolated impaired glucose tolerance (i-IGT), and combined IFG/IGT.
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Integrating ecological and genetic data into the framework used here has provided a powerful way to evaluate the relative contribution of genetic and ecological divergence for the development of isolating mechanisms between closely related taxa (see also [ 13, 14, 42]).
We evaluated the effect of the polymorphism on the subsequent development of isolated intracranial hemorrhage and white matter disease in preterm infants with a birth weight <1500 g (very low birth weight [VLBW] infants).
However, VLBW infants who carried the factor XIII 34Leu allele also had a moderately increased risk of the subsequent development of isolated intraventricular hemorrhage (14.3% vs 10.1% in infants without the mutation, P =.17).
Seismic, sedimentary and structural features are discussed regarding the influence of the plateau evolution on controlling the development of the isolated deposition along the eastern border of the Northern Puna.
The origin of this maximum could be ascribed to the right balance between the presence of very strong Lewis acid sites and the development of V5+ isolated sites in the matrix of the vanadyl pyrophosphate, by far the major crystalline phase present in the catalyst.
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