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The development of complement inhibitors has greatly improved the outcome of patients with atypical hemolytic uremic syndrome (aHUS), making kidney transplantation a more feasible option.
The history of the development of complement system inhibitors, preventing its destructive action on the body, represents the evolution of the main methods of drug design.
According to Axel-Tober, such a structure gave rise to the development of complement clauses; see the Old High German example in 4 with a silent correlative element, in which the thaz-clause is taken to function as a complement clause and thaz 'that' is the declarative complementizer triggering the verb-final position.
Probably, it could be possible in the future to use complement inhibitors as part of vaccines designed to block the development of complement sensitive pathogens in their vectors.
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Their work led to the development of the complement-fixation test, a diagnostic technique that was used to detect the presence of infectious agents in the blood, including those that cause typhoid, tuberculosis, and, most notably, syphilis (the Wassermann test).
The existence of complement inhibitors may have important biological consequences regarding a possible interference in the formation of anti-salivary antibodies by the hosts and the survival and development of complement sensitive pathogens in the vectors.
Together, these findings demonstrate that a single copy of Lhx6 LacZ supports the development of a normal complement of MGE-derived cortical interneurons, highlighted by normal tangential migration and distribution into cortical layers.
While multiple factors influence the development of LN, including complement, autoantibodies, environment, and genetics [ 17], the majority of these approaches only measure single analytes, and may not capture the clinical heterogeneity in SLE.
This suggests that podocyte injury may result in the development of PIG irrespective of complement activation.
The specific inhibition of gene expression by small interfering RNAs (siRNAs) provides a new approach to investigate the functions of oncogenes in the development of cancer, thereby complementing other approaches such as ectopic (over-) expression [ 34- 36].
These processes often support the development of AFN practices that complement rural/urban links.
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